Assessment of Immunoreactivity against Therapeutic Options Employing the Leukocyte Adherence Inhibition Test as a Tool for Precision Medicine

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  •   Celso Eduardo Olivier

  •   Daiana Guedes Pinto

  •   Regiane Patussi dos Santos Lima

  •   Mariana Dias da Silva

  •   Raquel Acácia Pereira Gonçalves dos Santos

  •   Ana Paula Monezzi Teixeira

  •   Patricia Ucelli Simioni

Abstract

Background: The Precision Medicine’s approach employs the endotype concept as a central feature to personalize medical treatment. Individual immunoreactivity, alongside characteristics such as genetics, environment, and diet, is one of the factors that differentiates the therapeutic-driven endotypes.


Objective: To evaluate the opportunity of the Leukocyte Adherence Inhibition test to differentiate the immunoreactivity between two similar therapeutic agents employed on Allergen Immunotherapy.


Methods: Side by side Leukocyte Adherence Inhibitions tests were performed with ovalbumin and carbamylated ovalbumin on a population of 33 self-reported egg-allergic individuals.


Results: The results showed two endotypes inside the immune response of the studied groups: The first endotype was defined by the 16 individuals that presented a significant decrease in ovalbumin’s immunoreactivity after carbamylation (mean of differences = 35%; p = 0.002). The second endotype was defined by 17 individuals that presented a significant increase in ovalbumin’s immunoreactivity after carbamylation (mean of differences = 32%; p = 0.001).


Conclusion: The Leukocyte Adherence Inhibition test was able to differentiate two distinct immunoreactivity patterns when comparing two similar therapeutic agents suggesting, as proof of concept, a potential role to be employed as a Precision Medicine tool.


Keywords: Allergoids, Leukocyte Adherence Inhibition test, Hypersensitivity, Precision Medicine

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How to Cite
Olivier, C. E., Pinto, D. G., Lima, R. P. dos S., Silva, M. D. da, Santos, R. A. P. G. dos, Teixeira, A. P. M., & Simioni, P. U. (2021). Assessment of Immunoreactivity against Therapeutic Options Employing the Leukocyte Adherence Inhibition Test as a Tool for Precision Medicine. European Journal of Clinical Medicine, 2(3), 40-45. https://doi.org/10.24018/clinicmed.2021.2.3.81